Parkinson’s is a dreadful neurodegenerative condition that starts gradually to become a chronic mobility disorder. It results from the death of the midbrain region; substantia nigra, which synthesis dopamine. The death of the substantia nigra causes reduced dopamine levels which may affect a persons motor skills. On the onset of PD (Parkinson’s Disease), an individual may experience rigidity, shaking, slugged motion, change of gait and pain when walking. In the advanced phases of the condition, the patient may suffer cognition impairment.
Even though the disorder is prevalent in the elderly generation, its onset may be hard to detect since most of the signed get associated with old- age.
Once you experience the below symptoms parkinson’s treatments is advisable so that you can conduct a normal lifestyle.
Besides the muscle stiffness, difficulty in movement other indicators of the condition include;
· Stooped gait
· Blank stare
· Change of voice
· Loss of smell senses
· Emotional distress
· Swallowing and chewing difficulties
· Skin problems.
Although the main cause of the disease is not known, it is sometimes attributed to
· genetic links
Family history may play a role in the development of the condition in close relatives. However, it is in a rarity for it to be genetic. Several factors are believed to play a part in the development of the condition.
· Low Dopamine Levels
Dopamine serves as the neurotransmitter to the brain cells responsible for coordination and movement. Upon the death of the substantial cells, the basal ganglia of the brain get affected.
The brain receives less of the messages to respond to stimuli, resulting to difficulty in movement. Since the condition progresses with time, it becomes more severe when dopamine production ceases.
· Low norepinephrine
Norepinephrine is a crucial automatic neurotransmitter. It is majorly responsible for the maintained blood circulation. When a person has PD, the nerve ending producing norepinephrine dies.
Therefore, a person may experience movement difficulties, fatigue, constipation, orthostatic hypotension and lightheadedness.
· Lewy bodies
Neurons of individuals having Parkinson’s have abnormal structures. They feature clumped proteins which form a reddish pink mass in the cytoplasm of the substantia nigra. A gene mutation on the alpha-synuclein protein of the Lewy bodies can also be a cause of the PD condition. This may cause Lewy body dementia which links to Parkinson’s.
· Autoimmune factors
Studies have shown that PD closely links to autoimmune disorders such as rheumatoid arthritis. In a research conducted in 2018, people having autoimmune rheumatoid diseases were more prone to developing Parkinson’s disease than those without.
The disease is rampant in elderly adults of over sixty years.
Research has shown that men have a higher chance of getting PD than women.
3. Exposure to toxins
Environmental factors such as contact to toxins such as carbon disulfide and pesticides might be factors that propagate Parkinson’s disease.
These substances kill the dopamine secreting cells resulting in PD. Also, toxins such as MPTP which was produced unintentionally during the manufacture of synthetic heroin poses a great danger to the substantia nigra cells.
To date, there is no known cure for the condition. However, medication such as levodopa and dopamine agonists are used to cure the motor symptoms. Early diagnosis is required to curb the condition early.